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GlossaryMicroglia

specialized immune cells in the brain and spinal cord

Microglia are specialized immune cells located in the brain and spinal cord that act as the main form of active immune defense in the central nervous system. They constantly monitor the environment for signs of damage or infection and can engulf and destroy pathogens, clear away dead cells, and release signaling molecules to modulate inflammation and repair processes.

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research Three-Dimensional Analysis of Sex- and Gonadal Status-Dependent Microglial Activation in a Mouse Model of Parkinson's Disease

2 citations, January 2023 in “Pharmaceuticals”

Sex and sex hormones can affect brain inflammation in Parkinson's disease, with male mice being more affected and female mice showing a protective effect.

research Microglia: Sculptors of the Polycystic Ovary Syndrome-Like Brain?

1 citations, June 2023 in “Reproduction”

Microglia, the brain's immune cells, may contribute to Polycystic Ovary Syndrome (PCOS) by altering the female brain's structure and function, with kisspeptin neurons and GABA neurotransmitters also playing a role.

Extracellular Vesicles Released by Hair Follicle and Adipose Mesenchymal Stromal Cells Induce Comparable Neuroprotective and Anti-Inflammatory Effects in Primary Neuronal and Microglial Cultures

research Extracellular Vesicles Released by Hair Follicle and Adipose Mesenchymal Stromal Cells Induce Comparable Neuroprotective and Anti-Inflammatory Effects in Primary Neuronal and Microglial Cultures

May 2023 in “Cytotherapy”

Hair follicle and adipose cell vesicles both protect neurons and reduce inflammation similarly.

research Exome-Wide Age-Of-Onset Analysis Reveals Exonic Variants In ERN1 And SPPL2C Associated With Alzheimer’s Disease

12 citations, February 2021 in “Translational Psychiatry”

Researchers found two new genetic variants linked to Alzheimer's disease.

Direct Implantation of Hair-Follicle-Associated Pluripotent Stem Cells Repairs Intracerebral Hemorrhage and Reduces Neuroinflammation in Mouse Model

research Direct Implantation of Hair-Follicle-Associated Pluripotent Stem Cells Repairs Intracerebral Hemorrhage and Reduces Neuroinflammation in Mouse Model

3 citations, January 2023 in “PloS one”

Implanting hair-follicle stem cells in mice brains helped repair brain bleeding and reduced brain inflammation.

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community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

in Satire 723 upvotes 1 year ago

The conversation is about the difference in hair loss between bodybuilders in the "Golden Era" and modern bodybuilders. Some users speculate that factors such as the types and doses of steroids used, genetics, diet, microplastics, and overall health may contribute to hair loss. Hair loss prevention medication and transplants are mentioned as potential treatments.

community Shampoo for a thicker appearance

in Advice 21 upvotes 4 years ago

A user recommends a biotin collagen shampoo for making hair appear thicker and feeling nice. Another user mentions using a similar product with argan oil from Walmart.

community 1mg and .5mg finasteride inhibit roughly the same amount of DHT, but have studies ever directly compared the two when just looking at regrowth?

in Finasteride/Dutasteride 12 upvotes 6 months ago

The conversation is about whether taking 0.5mg of finasteride daily is as effective as 1mg for hair regrowth and if there are long-term studies supporting the lower dose. The user is considering the lower dose to save money and reduce concerns about side effects.

community 3 Year Update (26m) (fin, min, micro needling, nizoral)

in Progress Pictures 155 upvotes 2 years ago

Hair loss treatment with finasteride, minoxidil, microneedling, and nizoral shows impressive results after 3 years. Dermatologist recommended starting with finasteride before adding other treatments.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 2 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

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