Construction of Tissue-Engineered Nerve Conduits Seeded with Neurons Derived from Hair-Follicle Neural Crest Stem Cells

    January 2016 in “ Methods in molecular biology ”
    Fang Liu, Hao Lin, Chuansen Zhang
    Studysummary This report introduces a tissue-engineered nerve conduit combining hfNCSCs-derived neurons and acellular nerve grafts to potentially repair long-distance peripheral nerve injuries. Our plain-language summary of this paper — not a Tressless recommendation.
    The study described the construction of tissue-engineered nerve conduits using neurons derived from hair-follicle neural crest stem cells (hfNCSCs) to repair peripheral nerve injuries with long defects. These hfNCSCs-derived neurons were seeded into acellular sciatic nerve scaffolds from beagles, which maintained intact collagen structure, biocompatibility, and low toxicity. The goal was to develop a novel therapeutic approach for repairing long-distance peripheral nerve injuries.
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