The Beneficial Effects of Chick Embryo Extract Preconditioning on Hair Follicle Stem Cells: A Promising Strategy to Generate Schwann Cells
January 2023
in “
Cell proliferation
”
chick embryo extract hair follicle stem cells epidermal neural crest stem cells EPI-NCSCs osteogenic lineage growth factors BDNF GDNF VEGF glial cells myelin sheath Schwann cells CEE stem cells neural crest stem cells bone formation brain-derived neurotrophic factor glial cell line-derived neurotrophic factor vascular endothelial growth factor nerve cells nerve insulation nerve support cells
TLDR Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.
The study investigated the effects of chick embryo extract (CEE) on hair follicle stem cells, specifically epidermal neural crest stem cells (EPI-NCSCs). The researchers found that CEE significantly enhanced the migration, proliferation, and colony-forming efficiency of these stem cells. CEE also directed the fate of these cells towards the osteogenic lineage and increased the expression of growth factors BDNF, GDNF, and VEGF. The study also found that CEE treatment led to the expression of proteins associated with glial cells and the myelin sheath in the central nervous system, suggesting that CEE may guide the differentiation of these stem cells towards the glial lineage, specifically into Schwann cells. The researchers concluded that CEE treatment might serve as a preconditioning strategy to enhance the baseline expression of BDNF, making them a proper cell type for transplantation under conditions like ischemic stroke.
