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GlossaryGlial Cell Line-Derived Neurotrophic Factor

promotes neuron survival and growth, especially dopamine-producing ones

Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a protein that promotes the survival and growth of neurons, the cells responsible for transmitting information in the nervous system. It is particularly important for the maintenance and repair of certain types of neurons, including those that produce dopamine, which are crucial for motor control and are affected in diseases like Parkinson's.

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research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations , January 2014 in “BioMed research international”

Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.

research Age-Associated Decrease in GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Human Skin

2 citations , June 2016 in “International journal of experimental pathology”

Human skin has less GDNF and its receptor with age.

GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

research GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

2 citations , January 2022 in “Experimental Dermatology”

GDNF signaling helps in hair growth and skin healing after a wound.

research Reawakening GDNF's Regenerative Past in Mice and Humans

1 citations , April 2022 in “Regenerative Therapy”

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

Psychological Stress Impact on Neurotrophic Factor Levels in Patients With Androgenetic Alopecia and Correlation With Disease Progression

research Psychological Stress Impact on Neurotrophic Factor Levels in Patients With Androgenetic Alopecia and Correlation With Disease Progression

October 2024 in “World Journal of Psychiatry”

Stress worsens hair loss in androgenetic alopecia.

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community Please explain this Minoxidil phenomena

in Minoxidil 58 upvotes 2 years ago

The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

community Why do people here trust Kevin Mann?

in Chat 35 upvotes 5 years ago

Concerns about finasteride's side effects on neurosteroids and brain health, with skepticism towards Kevin Mann's advice. Users discuss using finasteride, minoxidil, and RU58841 for hair loss, with mixed opinions on their safety and effectiveness.