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GlossaryGlial Cell Line-Derived Neurotrophic Factor

promotes neuron survival and growth, especially dopamine-producing ones

Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a protein that promotes the survival and growth of neurons, the cells responsible for transmitting information in the nervous system. It is particularly important for the maintenance and repair of certain types of neurons, including those that produce dopamine, which are crucial for motor control and are affected in diseases like Parkinson's.

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Expression patterns of the glial cell line–derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles

research Expression patterns of the glial cell line–derived neurotrophic factor, neurturin, their cognate receptors GFRα-1, GFRα-2, and a common signal transduction element c-Ret in the human skin hair follicles

18 citations , February 2008 in “Journal of The American Academy of Dermatology”

Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.

GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration

research GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration

2 citations , January 2022 in “Experimental Dermatology”

GDNF signaling helps in hair growth and skin healing after a wound.

research Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells

10 citations , January 2014 in “BioMed research international”

Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.

research GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells

7 citations , June 2020 in “npj regenerative medicine”

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

research Age‐associated decrease in GDNF and its cognate receptor GFRα‐1 protein expression in human skin

2 citations , June 2016 in “International journal of experimental pathology”

Human skin has less GDNF and its receptor with age.

research Reawakening GDNF's regenerative past in mice and humans

1 citations , June 2022 in “Regenerative Therapy”

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells

research The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells

5 citations , January 2023 in “Cell proliferation”

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

271 citations , May 2019 in “Cells”

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

research Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning

320 citations , December 2018 in “Frontiers in Immunology”

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

research Therapeutic potential of hair follicle-derived stem cell intranasal transplantation in a rat model of ischemic stroke

8 citations , July 2022 in “BMC neuroscience”

Transplanted hair follicle stem cells improved brain function and reduced damage after a stroke in rats.

research Regeneration of skin appendages and nerves: current status and further challenges

71 citations , February 2020 in “Journal of Translational Medicine”

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.

research Transforming growth factor-β in stem cells and tissue homeostasis

245 citations , January 2018 in “Bone Research”

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

research Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang

26 citations , May 2021 in “International Journal of Molecular Sciences”

Cheonggukjang may help prevent and manage various diseases and improve overall health, but its odor and safety concerns need addressing.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer

88 citations , August 2014 in “Journal of the American Academy of Dermatology”

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

research Nanotechnology-based techniques for hair follicle regeneration

November 2023 in “Biomaterials”

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression

research Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression

51 citations , December 2003 in “The FASEB Journal”

The substance AS101 can help hair grow by slowing down hair cell aging and boosting a hair growth protein.

research Hairy tale of signaling in hair follicle development and cycling

161 citations , October 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells

8 citations , November 2020 in “Frontiers in Cell and Developmental Biology”

Certain genes are more active in baby scalp cells and can help grow hair when added to adult mouse skin cells.

research PNKP is required for maintaining the integrity of progenitor cell populations in adult mice

3 citations , July 2021 in “Life science alliance”

PNKP is essential for keeping adult mouse progenitor cells healthy and growing normally.

research Platelet-rich Plasma and Cell Therapy

11 citations , July 2021 in “Dermatologic clinics”

PRP and cell therapies may help with hair loss, but more research is needed.

Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

research Growth factor concentrations in platelet‐rich plasma for androgenetic alopecia: An intra‐subject, randomized, blinded, placebo‐controlled, pilot study

13 citations , March 2020 in “Experimental Dermatology”

PRP growth factor concentrations vary, no significant hair growth difference found.

research Stem Cells and the Niche: A Dynamic Duo

333 citations , February 2010 in “Cell Stem Cell”

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

research Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation

18 citations , November 2020 in “Frontiers in Cell and Developmental Biology”

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

research Immunohistochemical Study on the Hair Growth Promoting Effect of Yonnyuniksoogobon-dan

1 citations , November 2008

Yonnyuniksoogobon-dan taken orally promotes hair growth by affecting growth factors in hair roots.

research Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables

86 citations , December 2001 in “Experimental dermatology”

Mutant mice help researchers understand hair growth and related genetic factors.

research SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells

77 citations , March 2017 in “Stem Cell Reports”

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.