GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

    January 2022 in “ Experimental Dermatology
    Neda Vishlaghi, Sandra Rieger, Vanessa McGaughey, Thomas S. Lisse
    Image of study
    TLDR GDNF signaling helps in hair growth and skin healing after a wound.
    The document discusses the role of Glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRA1 in hair follicle formation and skin regeneration. The study found that these factors are expressed in crucial cells of hair follicles and may play a significant role in wound healing and wound-induced hair neogenesis (WIHN). The research suggests that GDNF-GFRA1 signaling directs the fate of dermal fibroblasts, promoting WIHN and skin regeneration. The study plans to test this hypothesis using large-wound assays in house mice. The document also proposes that the GDNF signaling program could be repurposed to promote skin and appendage regeneration in less-regenerative organisms, potentially laying the groundwork for future GDNF-based treatments for impaired wound healing and tissue regeneration. Future studies will focus on understanding the regulation of GDNF-based programs to enable human regeneration.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    1 / 1 results

      community Please explain this Minoxidil phenomena

      in Minoxidil  60 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

    Related Research

    4 / 4 results