GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

    January 2022 in “ Experimental Dermatology
    Neda Vishlaghi, Sandra Rieger, Vanessa McGaughey, Thomas S. Lisse
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    TLDR GDNF signaling helps in hair growth and skin healing after a wound.
    The document discusses the role of Glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRA1 in hair follicle formation and skin regeneration. The study found that these factors are expressed in crucial cells of hair follicles and may play a significant role in wound healing and wound-induced hair neogenesis (WIHN). The research suggests that GDNF-GFRA1 signaling directs the fate of dermal fibroblasts, promoting WIHN and skin regeneration. The study plans to test this hypothesis using large-wound assays in house mice. The document also proposes that the GDNF signaling program could be repurposed to promote skin and appendage regeneration in less-regenerative organisms, potentially laying the groundwork for future GDNF-based treatments for impaired wound healing and tissue regeneration. Future studies will focus on understanding the regulation of GDNF-based programs to enable human regeneration.
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