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GlossaryGlial Cell Line-Derived Neurotrophic Factor (GDNF)

promotes neuron survival and growth, especially dopamine-producing ones

Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a protein that promotes the survival and growth of neurons, the cells responsible for transmitting information in the nervous system. It is particularly important for the maintenance and repair of certain types of neurons, including those that produce dopamine, which are crucial for motor control and are affected in diseases like Parkinson's.

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research GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells

7 citations, June 2020 in “npj regenerative medicine”

GDNF helps grow hair and heal skin wounds by acting on hair stem cells.

GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

research GDNF Neurotrophic Factor Signaling Determines the Fate of Dermal Fibroblasts in Wound-Induced Hair Neogenesis and Skin Regeneration

2 citations, January 2022 in “Experimental Dermatology”

GDNF signaling helps in hair growth and skin healing after a wound.

research Reawakening GDNF's Regenerative Past in Mice and Humans

1 citations, April 2022 in “Regenerative Therapy”

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

research Faculty Opinions Recommendation of GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells

January 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

GDNF helps grow hair and heal skin wounds by acting on specific stem cells.

research Age-Associated Decrease in GDNF and Its Cognate Receptor GFRα-1 Protein Expression in Human Skin

2 citations, June 2016 in “International journal of experimental pathology”

Human skin has less GDNF and its receptor with age.

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