Development of a Complex Skin Organ in Human Induced Pluripotent Stem Cell-Derived Organoids

    April 2023 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    A. Shafiee, J. Sun, I. Ahmed, J. Brown, K. Khosrotehrani
    Image of study
    TLDR Scientists created skin-like structures from stem cells that include features like hair and sweat glands.
    Researchers have developed protocols to create complex skin organoids (SKOs) from human induced pluripotent stem cells (hiPSCs) that include skin appendages such as hair follicles, sebaceous glands, sweat glands, fat, and touch-receptive Merkel cells. Using three different hiPSC lines, they observed the formation of hair placodes by Day 65, which developed into hair follicles by Day 83, and confirmed the presence of various stem/progenitor populations by Day 120. These SKOs, which mimic the cellular composition and architecture of second-trimester fetal skin tissues, represent a significant advancement in understanding hair follicle morphogenesis, modeling developmental skin diseases, and potential applications in skin reconstructive surgeries.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 852 results

      community Please explain this Minoxidil phenomena

      in Minoxidil  56 upvotes 1 year ago
      The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

    Related Research

    6 / 6 results