Non-Histone Methylation of SET7/9 and Its Biological Functions

December 2021 in “ Recent patents on anti-cancer drug discovery ”

Peng Song, Qing Li, L. Gao, Wenbin Yu

SET7/9 lysine methyltransferase methylation cell proliferation transcription regulation protein stability hair loss

Studysummary This review examines the role of SET7/9 in non-histone methylation and its implications in various diseases, including cancer, but presents no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

SET7/9, a lysine methyltransferase, methylates both histone and non-histone proteins, influencing cell proliferation, transcription regulation, and protein stability. It is crucial in the development and progression of diseases like hair loss, cancers, atherosclerosis, chronic kidney disease, diabetes, obesity, and pulmonary fibrosis. Its broad substrate range connects it to tumorigenesis and other pathological conditions.

View this study on eurekaselect.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

48 citations , September 2011 in “British Journal of Dermatology”

This study found that DNA methylation and histone modification status were altered in peripheral blood mononuclear cells of patients with alopecia areata, suggesting these changes may contribute to the disease's pathological immune responses.