The Impact of VDR Expression and Regulation In Vivo

    June 2017 in “ Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology ”
    Seong Min Lee, Mark B. Meyer, Nancy A. Benkusky, Charles A. O’Brien, J. Wesley Pike
    TLDR VDR regulation varies by tissue and is crucial for its biological functions.
    The study investigated the role of Vitamin D Receptor (VDR) expression and regulation in vivo, focusing on its impact on hair growth and alopecia. Researchers found that VDR is crucial for the maintenance of hair follicle health and that its absence or dysfunction can lead to hair loss. Using transgenic and knockout mouse models, they identified regulatory regions responsible for VDR expression in various tissues and demonstrated that even low VDR levels could rescue the VDR-null phenotype. The findings suggested that enhancing VDR activity could be a potential therapeutic strategy for treating hair loss conditions and provided significant insights into the molecular pathways involving VDR, highlighting its importance in dermatological health.
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