Calcitriol-Resistant Rickets With Alopecia

May 1985 in “ Archives of Dermatology ”

Zeev Hochberg

alopecia calcitriol vitamin D calcitriol-resistant rickets hair follicles hair loss rickets

TLDR Calcitriol-resistant rickets is an inherited disorder that affects hair growth and causes hair loss.

Four children from two related families exhibited alopecia and severe rickets that were resistant to treatment due to defective cytoplasmic and nuclear receptors for calcitriol, the active form of vitamin D. Despite the alopecia, scalp biopsies showed a normal number and appearance of hair and hair follicles. The study suggested that calcitriol-resistant rickets should be recognized as an inherited disorder affecting hair growth, and the combination of rickets and alopecia should be considered in diagnosing hair loss.

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Research cited in this study

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research 1,25-Dihydroxyvitamin D Resistance, Rickets, and Alopecia

110 citations , November 1984 in “The American Journal of Medicine”

A genetic defect in vitamin D receptors causes severe rickets and hair loss in children, but some heal as they age.

research Vitamins and Alopecia

6 citations , October 1980 in “Archives of Dermatology”

Vitamin deficiencies, especially biotin and vitamin D, can cause hair loss.

research Alopecia in Crash Dieters

23 citations , June 1976 in “PubMed”

Crash dieting can cause temporary hair loss due to not getting enough energy for hair growth.

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research Calcitriol-Resistant Rickets With Alopecia

55 citations , May 1985 in “Archives of Dermatology”

Calcitriol-resistant rickets is an inherited disorder that affects hair growth and causes hair loss.