Calcitriol-Resistant Rickets With Alopecia

The document discussed a study involving four children from two families who exhibited alopecia and severe rickets that were resistant to treatment due to defective cytoplasmic and nuclear receptors for calcitriol, the active form of vitamin D. Despite the alopecia, scalp biopsies showed a normal number and appearance of hair and hair follicles. The study suggested that calcitriol-resistant rickets should be recognized as an inherited disorder affecting hair growth and highlighted the importance of considering the association of rickets with alopecia in diagnosing hair loss.