Calcitriol-Resistant Rickets With Alopecia
May 1985
in “
Archives of Dermatology
”
New to Vitamin D? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that alopecia in four children was linked to severe calcitriol-resistant rickets, suggesting this condition should be considered among inherited hair growth disorders. Our plain-language summary of this paper — not a Tressless recommendation.
Four children from two related families exhibited alopecia and severe rickets that were resistant to treatment due to defective cytoplasmic and nuclear receptors for calcitriol, the active form of vitamin D. Despite the alopecia, scalp biopsies showed a normal number and appearance of hair and hair follicles. The study suggested that calcitriol-resistant rickets should be recognized as an inherited disorder affecting hair growth, and the combination of rickets and alopecia should be considered in diagnosing hair loss.
