In Situ Detection of Retinoid-X Receptor Expression in Normal and Psoriatic Human Skin

August 1995 in “ British journal of dermatology/British journal of dermatology, Supplement ”

Jörg Reichrath, Thomas Münßinger, A. Kerber, Cécile Rochette‐Egly, Pierre Chambon, Friedrich A. Bahmer, Hans-Peter Baum

retinoid-X receptor RXR RXR-alpha keratinocytes melanocytes fibroblasts immune cells nuclear staining cytoplasmic staining psoriasis vulgaris epidermal keratinocytes hair follicles hair growth RXR RXR-alpha skin cells psoriasis hair growth

TLDR RXR-alpha is strongly expressed in both normal and psoriatic skin and may help in skin cell differentiation and hair growth.

The study developed a new immunohistochemical technique to detect retinoid-X receptor (RXR) expression in human skin and found that RXR-alpha was strongly expressed in both normal and psoriatic skin. RXR-alpha was present in various cell types, including keratinocytes, melanocytes, fibroblasts, and immune cells, with strong nuclear and less cytoplasmic staining. The study concluded that altered RXR-alpha levels or distribution were not involved in psoriasis vulgaris genesis but suggested a role in the transition from proliferation to differentiation in epidermal keratinocytes. Additionally, RXR-alpha expression in hair follicles indicated a potential contribution to hair growth.

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