Expression of Retinoid-X Receptors (α, β, γ) and Retinoic Acid Receptors (α, β, γ) in Normal Human Skin: An Immunohistological Evaluation
January 1997
TLDR RXR and RAR proteins in skin may help with cell growth, hair growth, and gland function.
The study investigated the localization of retinoid-X receptors (RXR-AE,-â,-a) and retinoic acid receptors (RAR-AE,-â,-a) in normal human skin using immunohistochemistry on 12 skin samples. It was found that RXR and RAR proteins were present in the viable epidermis, with RAR-â being less consistently detected. The presence of these proteins in the stratum granulosum suggested a role in the transition from proliferation to differentiation in epidermal keratinocytes. Additionally, their expression in hair follicles, sebaceous glands, and endothelial cells indicated a potential role in hair growth and the physiology of sebaceous glands and endothelial cells.
