Cellular Localization of Retinoic Acid Receptor-Gamma Expression in Normal and Neoplastic Skin

June 1992 in “ PubMed ”

Eric Finzi, Michael Blake, P Celano, John Skouge, Rishi Diwan

retinoic acid receptor-gamma RAR-gamma epidermis hair follicles skin glands basal cell carcinoma squamous cell carcinoma melanocytic nevi keratinocyte

TLDR RAR-gamma 1 is important for normal skin maintenance and differentiation.

The study investigated the expression of retinoic acid receptor-gamma (RAR-gamma) in normal and neoplastic human skin using Northern blot analysis and in situ hybridization. RAR-gamma mRNA was found in normal skin, neonatal keratinocyte cultures, and various skin structures such as the epidermis, hair follicles, and glands. Basal cell carcinoma consistently expressed RAR-gamma 1 mRNA, while one out of seven squamous cell carcinomas showed a loss of this expression compared to adjacent tissue. In contrast, normal melanocytic nevi and tumor-associated lymphocytes showed little to no RAR-gamma mRNA expression. These findings suggested that RAR-gamma 1 played a crucial role in maintaining and differentiating normal epidermis and skin appendages.

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research Cellular Localization of Retinoic Acid Receptor-Gamma Expression in Normal and Neoplastic Skin

23 citations , June 1992 in “PubMed”

RAR-gamma 1 is important for normal skin maintenance and differentiation.