Annotated Patent Selections

The document "Annotated Patent Selections" from January 1, 2000, summarized various patents for novel compounds and their potential therapeutic uses. Highlights included treatments for prostate cancer, benign prostatic hyperplasia, breast cancer, precocious puberty, endometriosis, uterine fibroids, acne, premenstrual syndrome, polycystic ovary syndrome, and thrombotic disorders. Specific compounds were claimed to inhibit enzymes like Factor Xa, thrombin, and serine proteases, showing promising IC50 values in vitro. Additionally, patents covered inhibitors of cyclin-dependent kinases for tumor treatment, erythromycin derivatives for hormone-related conditions, and novel inhibitors for Type 3 and 5 17β-hydroxysteroid dehydrogenase targeting androgenic alopecia and other conditions. The document also included claims for compounds targeting diabetes, cancer, inflammatory diseases, and viral infections, with detailed synthesis methods and specific compounds exemplified.