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    Did you mean 11β-Hydroxysteroid Dehydrogenase Type 1?
    Glossary11β-Hydroxysteroid Dehydrogenase Type 1

    enzyme converting inactive cortisone to active cortisol

    11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) is an enzyme that converts inactive cortisone into active cortisol, a hormone involved in stress response, metabolism, and immune function. This enzyme is found in various tissues, including the liver and adipose tissue, and plays a role in conditions like obesity, diabetes, and potentially hair loss due to its influence on local cortisol levels.

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      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

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      Frontline, gold standard treatment for combatting androgenic alopecia

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      community 3 month progress dut

      in Progress  313 upvotes 5 years ago
      User experienced rapid thinning on crown, used dutasteride for 3 months with significant improvement. Microneedling and ketoconazole were also used, but no minoxidil or finasteride.

      community Fin/Min/VitD 3 month progress pics

       115 upvotes 6 years ago
      A user shared their positive 3-month experience using finasteride, minoxidil, and vitamin D to treat hair loss, noting significant regrowth and minimal shedding. They also discussed potential side effects and the low likelihood of experiencing them, while being open to answering further questions.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 4 months ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.