Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

    May 2025 in “ Clinical Endocrinology
    Yasir Elhassan, James Hawley, Leanne Cussen, Ali Abbara, Sophie Clarke, Punith Kempegowda, Rima Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael O’Reilly
    TLDR Evaluate and manage androgen excess in women with a systematic approach, considering both physical and psychological impacts.
    The Society for Endocrinology's guideline provides a comprehensive approach to evaluating androgen excess in women, a condition affecting up to 10% of women of reproductive age, often presenting as hirsutism, acne, or virilization. It emphasizes distinguishing between polycystic ovary syndrome (PCOS) and other conditions like congenital adrenal hyperplasia (CAH), ovarian hyperthecosis, and virilising ovarian tumors. The guideline highlights the role of insulin in amplifying ovarian androgen production and the importance of a systematic diagnostic approach, including biochemical workups and imaging techniques. It underscores the need for specialist-guided management, considering metabolic disorders and cardiovascular risks associated with androgen excess. The document stresses the psychological impact of symptoms and calls for improved education and resources for better management and patient satisfaction.
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