Differential Suppression of Testosterone and Estradiol in Hirsute Women With the Superactive Gonadotropin-Releasing Hormone Agonist Leuprolide

    October 1988 in “ The Journal of Clinical Endocrinology & Metabolism ”
    Roger S. Rittmaster
    Studysummary This study found that low doses of leuprolide effectively suppressed serum estradiol and LH response, while higher doses were needed to suppress testosterone and reduce hair growth in hirsute women.
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    Research cited in this study 4

    1. Clinical and Hormonal Effects of Chronic Gonadotropin-Releasing Hormone Agonist Treatment in Polycystic Ovarian Disease The Journal of Clinical Endocrinology & Metabolism · 1987
    2. Clinical Usefulness of Plasma Androstanediol Glucuronide Measurements in Women with Idiopathic Hirsutism ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1987
    3. Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin) ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1986
    4. 3 Alpha, 17 Beta-Androstanediol Glucuronide in Plasma: A Marker of Androgen Action in Idiopathic Hirsutism ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 1982