A Guide to Understanding Polycystic Ovary Syndrome (PCOS)

    March 2014 in “ Journal of Family Planning and Reproductive Health Care ”
    W. Colin Duncan
    TLDR PCOS is a common hormonal disorder in women, marked by high androgen levels and often seen in 20% of women via ultrasound.
    Polycystic ovary syndrome (PCOS) was a prevalent endocrine disorder affecting 7% of women of reproductive age, characterized by increased androgen production leading to symptoms like amenorrhea, hirsutism, and infertility. The condition was linked to insulin resistance, obesity, and heightened risks of type 2 diabetes and heart disease. The document explained the two-cell, two-gonadotrophin model of estrogen synthesis, highlighting how imbalances in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) increased androgen production. It also discussed the role of sex hormone binding globulin (SHBG) in regulating androgen bioavailability, with obesity reducing SHBG levels and worsening symptoms. Management strategies included using the combined oral contraceptive pill, promoting weight loss, and using metformin to improve insulin sensitivity. The guide aimed to enhance understanding and inform management strategies for PCOS, emphasizing the importance of endometrial protection and addressing hirsutism.
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      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

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      in Female  54 upvotes 2 years ago
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      in Female  450 upvotes 2 years ago
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