Ethnicity, Obesity, and the Prevalence of Impaired Glucose Tolerance and Type 2 Diabetes in PCOS: A Systematic Review and Meta-Regression

    March 2018 in “ Human Reproduction Update ”
    Nadira Sultana Kakoly, Mahnaz Bahri Khomami, Anju E. Joham, Shamil D. Cooray, Marie Misso, Robert J. Norman, Cheryce L. Harrison, Sanjeeva Ranasinha, Helena Teede, Lisa J. Moran
    Image of study
    TLDR Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.
    The document presents a systematic review and meta-regression analysis that included 40 eligible studies, which examined the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in women with polycystic ovary syndrome (PCOS). The analysis, which involved 4530 studies up to June 2016, found that women with PCOS had a significantly higher prevalence of IGT and T2DM, with odds ratios of 3.26 for IGT and 2.87 for T2DM. The prevalence varied by ethnicity, with the highest increase in Asia, followed by the Americas and Europe. Obesity was found to further increase the prevalence, and the use of self-report or administrative data for diagnosing diabetes doubled the prevalence. Despite the clear association between PCOS, ethnicity, and obesity with IGT and T2DM, the meta-regression did not identify specific contributors to the heterogeneity observed. The study underscores the importance of PCOS as a risk factor for dysglycemia and the need for accurate diabetes diagnostic methods, while also highlighting the influence of ethnicity and obesity.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 12 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 2 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Why balding gets worse in every generation?

      in Chat  81 upvotes 5 months ago
      Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

    Related Research

    1 / 1 results