The Polycystic Ovary Syndrome Evolutionary Paradox: A Genome-Wide Association Studies-Based, In Silico, Evolutionary Explanation

    August 2014 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Livio Casarini, Giulia Brigante
    Studysummary This study suggests that variations in PCOS phenotypes observed across different ethnic groups may be due to a genetic gradient resulting from historical human migrations and genetic drift.
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    Research cited in this study 6

    1. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology and Metabolism · 2013
    2. Phenotype and Metabolic Profile of South Asian Women with Polycystic Ovary Syndrome: Results from a Specialist Endocrine Clinic Human Reproduction · 2010
    3. Variations in Alanine Aminotransferase Levels Within the Normal Range Predict Metabolic and Androgenic Phenotypes in Women of Reproductive Age Scandinavian Journal of Clinical & Laboratory Investigation · 2010
    4. A Simple Screening Approach for Assessing Community Prevalence and Phenotype of Polycystic Ovary Syndrome in a Semiurban Population in Sri Lanka American Journal of Epidemiology · 2008
    5. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004
    6. A Prospective Study of the Prevalence of Polycystic Ovary Syndrome in Unselected Caucasian Women from Spain The Journal of Clinical Endocrinology and Metabolism · 2000