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Glossary allele

variant form of a gene at a specific chromosome location

An allele is a variant form of a gene that is located at a specific position, or locus, on a chromosome. Different alleles can result in different traits, such as hair color or susceptibility to certain conditions like alopecia. In diploid organisms, which include humans, each individual inherits two alleles for each gene, one from each parent, and the combination of these alleles determines specific characteristics.

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research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

This study demonstrated that RNA interference targeting mutant keratin genes can effectively correct hair shaft structural defects in a mouse model by reducing mutant gene expression.

research GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which are Attenuated by Finasteride

134 citations , February 2005 in “Neuropsychopharmacology”

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

research Hague (Hag): A New Mouse Hair Mutation With an Unstable Semidominant Allele

11 citations , October 2002 in “Genetics”

This study mapped a spontaneous mouse hair mutation, "hague," to keratin genes on chromosome 15 but found no gene mutations in hague mice.

Incidence of Adverse Cutaneous Drug Reactions in a Mexican Sample: An Exploratory Study on Their Association to Tumor Necrosis Factor Alpha TNF2 Allele

research Incidence of adverse cutaneous drug reactions in a Mexican sample: an exploratory study on their association to tumour necrosis factor alpha TNF2 allele

6 citations , March 2009 in “Journal of the European Academy of Dermatology and Venereology”

This study found no increased frequency of the TNF2 allele in Mexican patients with adverse cutaneous drug reactions mediated by delayed hypersensitivity, suggesting its lower relevance compared to findings in Caucasian populations.

research The Role of rs6152 Allele and Non-Genetic Factors in Androgenetic Alopecia: A Pilot Study in the Indonesian Local Population

March 2024 in “Bioscientia medicina”

In this study, rs6152 was not significantly associated with androgenetic alopecia in the Indonesian population, but familial history and factors like age, gender, hypertension, and BMI were strongly linked to AGA risk.

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