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GlossaryHomozygous

having two identical alleles for a specific gene

Homozygous refers to having two identical alleles for a particular gene. In simpler terms, if you inherit the same version of a gene from both your mother and your father, you are homozygous for that gene. This can influence traits such as hair color or susceptibility to certain conditions like alopecia. For example, if both alleles for a gene related to hair growth are the same, it can determine whether you have a full head of hair or are more prone to hair loss.

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research Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction

16 citations, September 2015 in “International Journal of Molecular Sciences”

A specific gene variant causes severe skin issues and increases infection risk, requiring careful medical monitoring.

research Homozygous Deletion in CDH3 and Hypotrichosis With Juvenile Macular Dystrophy

15 citations, November 2012 in “Archives of Ophthalmology”

A deletion in the CDH3 gene causes a rare disorder with short hair and vision loss.

research Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis

8 citations, June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A boy's skin fragility and sparse hair were caused by a genetic mutation affecting skin cell adhesion.

research Homozygous Whole Body Cbs Knockout in Adult Mice Features Minimal Pathology During Aging Despite Severe Homocysteinemia

7 citations, March 2022 in “The FASEB journal”

Adult mice with CBS deficiency show minimal health issues and normal lifespan despite high homocysteine levels.

research Disease Causing Homozygous Variants in the Human Hairless Gene

7 citations, December 2015 in “International Journal of Dermatology”

New and known mutations in the hairless gene cause a hair loss condition called Atrichia with papular lesions.

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community Recently went bald and will stop taking finasteride. Will stop taking it impact density in my beard and eyebrows? Also here’s after and before picture

in Shaved/buzzed 107 upvotes 2 months ago

The user recently went bald and plans to stop taking finasteride, questioning its impact on beard and eyebrow density. Responses suggest he looks good both bald and with thinning hair, with some recommending minoxidil for the crown and noting finasteride's effect on beard thickness.

community How to know if shedding is from tren or minoxidil?

in Minoxidil 5 upvotes 7 months ago

The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

community Dutasteride broked my liver (maybe)

in Finasteride/Dutasteride 8 upvotes 2 years ago

A user shared their experience with high cholesterol, glucose, and potential metabolic syndrome after using Finasteride and Dutasteride for hair loss. They plan to improve their health with diet and exercise before considering medication.