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    Glossary Homozygous

    having two identical alleles for a specific gene

    Homozygous refers to having two identical alleles for a particular gene. In simpler terms, if you inherit the same version of a gene from both your mother and your father, you are homozygous for that gene. This can influence traits such as hair color or susceptibility to certain conditions like alopecia. For example, if both alleles for a gene related to hair growth are the same, it can determine whether you have a full head of hair or are more prone to hair loss.

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    1. Homozygous Dominant Missense Mutation in Keratin 17 Leads to Alopecia in Addition to Severe Pachyonychia Congenita Journal of Investigative Dermatology · 2012 · 22 citations
    2. Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction International Journal of Molecular Sciences · 2015 · 16 citations
    3. Homozygous Deletion in CDH3 and Hypotrichosis With Juvenile Macular Dystrophy Archives of Ophthalmology · 2012 · 15 citations
    4. Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis 2020 · 8 citations
    5. Homozygous whole body <i>Cbs</i> knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia ˜The œFASEB journal · 2022 · 7 citations
    6. Disease causing homozygous variants in the human hairless gene International Journal of Dermatology · 2015 · 7 citations
    7. Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis Molecular Carcinogenesis · 2006 · 7 citations
    8. The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome Case reports in genetics · 2015 · 7 citations
    9. A homozygous missense mutation in the fibroblast growth factor 5 gene is associated with the long-hair trait in Angora rabbits BMC genomics · 2023 · 5 citations
    10. A Homozygous Missense Variant in K25 Underlying Overlapping Phenotype with Woolly Hair and Dental Anomalies 2022 · 2 citations
    11. Homozygous missense mutation in the<i>LIPH</i>gene causing autosomal recessive hypotrichosis simplex in a Chinese patient Journal of dermatology · 2013 · 2 citations
    12. A homozygous nonsense mutation identified in <i>COL7A1</i> in a family with autosomal recessive dystrophic epidermolysis bullosa Journal of Medicine and Life · 2024
    13. Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma (PRP) for Treating Androgenic Alopecia Aesthetic Plastic Surgery · 2017 · 24 citations
    14. Homologous recombination induced by doxazosin mesylate and saw palmetto in the <i>Drosophila</i> wing‐spot test 2011 · 3 citations
    15. A Homozygous Nonsense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia Journal of Investigative Dermatology · 1999 · 37 citations
    16. A Homozygous Frameshift Mutation in the<i>HOXC13</i>Gene Underlies Pure Hair and Nail Ectodermal Dysplasia in a Syrian Family Human Mutation · 2013 · 30 citations
    17. A homozygous missense variant in type I keratin <i>KRT25</i> causes autosomal recessive woolly hair Journal of Medical Genetics · 2015 · 29 citations
    18. A homozygous single T deletion found in the GGCX gene with PXE-like phenotypes Journal of Dermatological Science · 2016
    19. In vivo expansion and regeneration of full‐thickness functional skin with an autologous homologous skin construct: Clinical proof of concept for chronic wound healing International Wound Journal · 2019 · 38 citations
    20. Three Novel Homozygous Point Mutations and a New Polymorphism in the COL17A1 Gene: Relation to Biological and Clinical Phenotypes of Junctional Epidermolysis Bullosa The American Journal of Human Genetics · 1997 · 80 citations
    21. Olmsted Syndrome Caused by a Homozygous Recessive Mutation in TRPV3 Journal of Investigative Dermatology · 2014 · 56 citations
    22. A novel PLEC nonsense homozygous mutation (c.7159G > T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report BMC dermatology · 2018 · 18 citations
    23. A novel homozygous variant in the dsp gene underlies the first case of non-syndromic form of alopecia Archives of Dermatological Research · 2015 · 2 citations
    24. Identification of a novel homozygous LAMB3 mutation in a Chinese male with junctional epidermolysis bullosa and severe urethra stenosis: A case report Frontiers in genetics · 2022
    25. Cutaneous xanthomas in homozygous familial hypercholesterolemia: A 12-year follow-up Journal of The American Academy of Dermatology · 2016
    26. Loss of a homologous group of proteins in a dominantly inherited ectodermal malformation Biochemical Journal · 1976 · 15 citations
    27. PROSPECT OF UTILIZING EXPIRED HOMOLOGOUS PLATELET CONCENTRATES AS AN ALTERNATIVE SOURCE OF GROWTH FACTORS AND CYTOKINES IN CLINICAL SETUP FOR BETTER WOUND CARE AND HEALING Asian Journal of Pharmaceutical and Clinical Research · 2024
    28. A Novel Gene Homologous to Teashirt is Differentially Expressed in Neonatal Mouse Skin During Development of Hair Follicles Molecular biotechnology · 2004
    29. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene 2002 · 94 citations
    30. The biochemical and phenotypic characterization of females homozygous for 5 alpha-reductase-2 deficiency. The Journal of Clinical Endocrinology & Metabolism · 1995 · 54 citations