Persistent Poor Metabolic Profile in Postmenopausal Women With Ovarian Hyperandrogenism After Testosterone Level Normalization

    April 2019 in “ Journal of the Endocrine Society ”
    Thaís Rocha, Raiane P Crespo, Viviane V R Yance, Sylvia Asaka Yamashita Hayashida, Edmund Chada Baracat, Filomena Marino Carvalho, Sorahia Domenice, Berenice Bilharinho Mendonca, Larissa Gomes
    Image of study
    TLDR Postmenopausal women with hyperandrogenism didn't have better metabolic health even after their testosterone levels became normal.
    The study focused on the metabolic profiles of 24 postmenopausal Brazilian women with ovarian hyperandrogenism, specifically those with virilizing ovarian tumors or ovarian hyperthecosis, who underwent bilateral oophorectomy between 2004 and 2014. The researchers measured obesity, hypertension, type 2 diabetes, and dyslipidemia prevalence, as well as BMI, fasting plasma glucose, glycated hemoglobin, and lipid levels before and 24 months after surgery. Initially, there were high rates of obesity (58.3%), type 2 diabetes (83.3%), dyslipidemia (66.7%), and hypertension (87.5%). However, even after testosterone levels normalized post-surgery, there were no significant improvements in these metabolic risk factors. The study concluded that long-term normalization of testosterone levels did not improve metabolic risk factors in postmenopausal women with hyperandrogenism.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 11 results

      community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

      in Update  35 upvotes 5 years ago
      The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

      community 11-month update. This time wet hair comparison!

      in Progress Pictures  108 upvotes 1 year ago
      The post discusses an 11-month hair loss treatment journey using dutasteride, minoxidil, nizoral, and 1.5mm derma rolling. The responses inquire about the frequency of derma rolling and express optimism for further progress.

      community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

      in Minoxidil  178 upvotes 1 month ago
      Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  53 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community My scalp punch biopsy results🤔?

      in Female  9 upvotes 1 year ago
      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

      community having hair loss as a teen SUCKS. A LOT.

      in Female  12 upvotes 2 years ago
      A teenage girl who has been diagnosed with ADA and is struggling with hair loss, which has caused her to lose confidence. She is looking for recommendations on treatments such as finasteride or Minoxidil, and lifestyle advice including vitamins and other supplements that might help with the issue.

    Related Research

    2 / 2 results