Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS

December 2022 in “ Journal of Clinical Medicine ”

Elisabeth Reiser, Julia Lanbach, Bettina Böttcher, Bettina Toth

metformin GLP-1RA GLP-1-agonists phytotherapeutic extracts antiandrogen medication polycystic ovary syndrome PCOS GLP-1 receptor agonists herbal medicines

TLDR Medications for glucose metabolism and weight control, combined therapy options, and herbal medicines may help regulate menstrual cycle in adolescents with PCOS.

The document discusses non-hormonal treatment options for regulating the menstrual cycle in adolescents with polycystic ovary syndrome (PCOS). It mentions that medications targeting glucose metabolism and weight control may be beneficial in improving menstrual frequency. Metformin shows overall benefit, while GLP-1RA and ROS have conflicting data. The document emphasizes the need for more studies in adolescents with PCOS and mentions the potential of GLP-1-agonists and phytotherapeutic extracts as promising treatment options. It also discusses the role of antiandrogen medication in improving menstrual frequency and the importance of effective contraception. The document concludes that combined therapy options and herbal medicines may have beneficial effects, but more research is needed.

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Research cited in this study

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research The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome

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Chromium salts may help with insulin sensitivity in PCOS, but more research is needed to confirm their overall effectiveness and safety.

A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

research A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

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Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

research Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

116 citations, December 2013 in “European journal of endocrinology”

Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.

Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

research Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

75 citations, July 2013 in “The Journal of Clinical Endocrinology and Metabolism”

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

research Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women

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Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS

Research cited in this study

research The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome

research A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

research Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study

research Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

research Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

research Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women

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