Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS

December 2022 in “ Journal of Clinical Medicine ”

Elisabeth Reiser, Julia Lanbach, Bettina Böttcher, Bettina Toth

metformin GLP-1RA GLP-1-agonists phytotherapeutic extracts antiandrogen medication polycystic ovary syndrome PCOS GLP-1 receptor agonists herbal medicines

TLDR Medications for glucose metabolism and weight control, combined therapy options, and herbal medicines may help regulate menstrual cycle in adolescents with PCOS.

The document discusses non-hormonal treatment options for regulating the menstrual cycle in adolescents with polycystic ovary syndrome (PCOS). It mentions that medications targeting glucose metabolism and weight control may be beneficial in improving menstrual frequency. Metformin shows overall benefit, while GLP-1RA and ROS have conflicting data. The document emphasizes the need for more studies in adolescents with PCOS and mentions the potential of GLP-1-agonists and phytotherapeutic extracts as promising treatment options. It also discusses the role of antiandrogen medication in improving menstrual frequency and the importance of effective contraception. The document concludes that combined therapy options and herbal medicines may have beneficial effects, but more research is needed.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome

4 citations, February 2019 in “Biological Trace Element Research”

Chromium salts may help with insulin sensitivity in PCOS, but more research is needed to confirm their overall effectiveness and safety.

A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

research A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

61 citations, January 2015 in “Hormones”

Liraglutide caused significant weight loss in some obese women with PCOS, especially those with severe obesity and insulin resistance.

research Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study

23 citations, February 2014 in “Journal of Pediatric and Adolescent Gynecology”

Low-dose finasteride reduces excessive hair growth in teenage girls safely and affordably.

Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

research Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

116 citations, December 2013 in “European journal of endocrinology”

Combining liraglutide and metformin helps obese women with PCOS who didn't lose weight on metformin alone to lose more weight.

Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

research Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

75 citations, July 2013 in “The Journal of Clinical Endocrinology and Metabolism”

Taking low-dose spironolactone and metformin together works better for PCOS symptoms than either drug alone.

research Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women

29 citations, September 2004 in “Fertility and Sterility”

Intermittent low-dose finasteride works as well as daily use for treating excessive hair growth in women.

Similar Research

5 / 1000+ results

research Metabolic Syndrome: A New Definition and Management Guidelines

11 citations, December 2022 in “Arterial Hypertension”

New guidelines stress early diagnosis and lifestyle changes to manage metabolic syndrome and prevent complications.

research Cardiovascular Profile of Pharmacological Agents Used for the Management of Polycystic Ovary Syndrome

4 citations, January 2019 in “Therapeutic Advances in Endocrinology and Metabolism”

Medications for PCOS don't seem to raise heart disease risk.

research Metabolic Syndrome – A New Definition and Management Guidelines: A Joint Position Paper by Various Polish Medical Societies

20 citations, August 2022 in “Archives of Medical Science”

The Polish medical societies have redefined metabolic syndrome and recommend lifestyle changes, certain medications, and possibly bariatric surgery for treatment. They also discuss managing related health conditions.

research The Potential Utility of Tirzepatide for the Management of Polycystic Ovary Syndrome

July 2023 in “Journal of Clinical Medicine”

Tirzepatide might help manage PCOS in obese patients but needs more research to confirm safety and effectiveness.

research Polycystic Ovary Syndrome (PCOS): An Inflammatory, Systemic, Lifestyle Endocrinopathy

317 citations, April 2018 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS

Research cited in this study

research The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome

research A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

research Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study

research Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

research Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

research Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women

Related Community Posts Join

community What treatment helps diffuse hair thinning from insulin resistance?

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

community Topical rapamycin, metformin, a-kg grow hair

community Finasteride and Metformin together?

community Research suggests that drugs rapamycin and metformin have hair regeneration properties