Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

    July 2013 in “ The Journal of Clinical Endocrinology and Metabolism ”
    Mohd Ashraf Ganie, Madan Lal Khurana, Shazia Nisar … Shahnaz Taing
    Studysummary This study found that combining low-dose spironolactone with metformin provided greater clinical benefits and improved treatment compliance in women with PCOS compared to either drug alone.
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    Research cited in this study 10

    1. Influence of Spironolactone Treatment on Endothelial Function in Non-Obese Women with Polycystic Ovary Syndrome European Journal of Endocrinology · 2011
    2. Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis Nature Reviews Endocrinology · 2011
    3. Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan BMC Medicine · 2010
    4. Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome European journal of endocrinology · 2009
    5. Spironolactone Versus Placebo or in Combination with Steroids for Hirsutism and/or Acne Cochrane library · 2009
    6. Evidence-Based and Potential Benefits of Metformin in Polycystic Ovary Syndrome: A Comprehensive Review Endocrine Reviews · 2008
    7. Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline The Journal of Clinical Endocrinology and Metabolism · 2006
    8. A Comparison Between Spironolactone and Spironolactone Plus Finasteride in the Treatment of Hirsutism European journal of endocrinology · 2004
    9. Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial The Journal of Clinical Endocrinology and Metabolism · 2000
    10. The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women Fertility and sterility · 1985