Comparison of Spironolactone and Spironolactone Plus Metformin in the Treatment of Polycystic Ovary Syndrome

    September 2015 in “ Gynecological Endocrinology ”
    Halit Diri, Sulbiye Karaburgu, Banu Acmaz, Kursad Unluhizarci, Fatih Tanriverdi, Zuleyha Karaca, Fahrettin Kelestimur
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    TLDR Both treatments reduced excessive hair growth in PCOS, but there was no difference in weight, hair score, hormone levels, or insulin resistance.
    The study from 2015 compared the effectiveness of spironolactone alone versus spironolactone combined with metformin in treating women with polycystic ovary syndrome (PCOS). It involved 37 patients, with 18 receiving only spironolactone and 19 receiving both medications. The treatments were found to significantly reduce hirsutism scores, but there was no significant difference between the two groups in terms of BMI, Ferriman-Gallwey scores, hormone levels, or insulin resistance. Additionally, 27% of patients on spironolactone experienced inter-menstrual vaginal bleeding. The small sample size limits the conclusiveness of the study, and further research with more participants is recommended.
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      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  55 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community C’est terrible - at my wits end

      in Female  450 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Year on oral minoxidil (1.75mg)

      in Update  6 upvotes 4 weeks ago
      The user experienced initial shedding but saw regrowth after seven months using oral minoxidil (1.75mg) and a dandruff shampoo. They plan to try Spironolactone and possibly metformin for PCOS-related hair issues.

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