Finasteride Versus Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism

    A. Beigi, Aya Sobhi, F. Zarrinkoub
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    TLDR Finasteride and CPA-EE2 equally reduce hirsutism, but affect hormone levels differently.
    The study compared the effectiveness of finasteride and a combination of cyproterone acetate (CPA) and ethinyl estradiol (EE2) in treating hirsutism in 40 women. Both treatments were equally effective in reducing hirsutism, but had different effects on hormone levels. Treatment with CPA plus EE2 significantly decreased serum total and free T, A, DHEAS, and DHT and increased SHBG levels, while finasteride significantly increased total T but reduced DHT levels. The study suggests that preventing the conversion of T to DHT by inhibiting 5 α-reductase activity could be a reasonable treatment in hirsutism.
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