The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome

The document reviewed the potential benefits of chromium III salts (Cr) supplementation as a supportive treatment for polycystic ovary syndrome (PCOS), focusing on its effects on insulin resistance, a common feature of PCOS. Animal studies have indicated positive effects on glucose and insulin levels, as well as body weight and liver health in a PCOS mouse model. Human clinical studies, including one with 35 adolescent girls and others totaling 137 women, have shown mixed outcomes, with some improvements in menstrual regularity and ovarian function, but inconsistent results regarding BMI, acne, hirsutism, and insulin levels compared to metformin. Meta-analyses suggest improved insulin sensitivity but no significant impact on testosterone, body mass, or serum lipids. The document concludes that while there is some evidence for the benefits of Cr in PCOS, particularly for insulin sensitivity, more research with larger sample sizes and longer study durations is needed to confirm its efficacy and safety, especially concerning mood disorders associated with PCOS.