Dermal White Adipose Tissue Development and Metabolism: The Role of Transcription Factor Foxn1

    September 2023 in “ ˜The œFASEB journal ”
    Katarzyna Walendzik, Marta Kopcewicz, Joanna Bukowska, Paulina Opyd, Sylwia Machcińska, Barbara Gawrońska‐Kozak
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    TLDR Foxn1 is important for fat development, metabolism, and wound healing in skin.
    The study investigates the role of the transcription factor Foxn1 in the development and metabolism of dermal white adipose tissue (dWAT) using Foxn1+/+ and Foxn1−/− mice models. Key findings indicate that Foxn1 significantly influences adipogenesis, lipid metabolism, and wound healing, with Foxn1+/+ mice showing increased expression of adipogenic and lipid metabolism-related genes. Foxn1 also affects the phenotype and function of dermal fibroblasts, modulating lipogenesis and lipolysis processes. The research highlights Foxn1's potential as a therapeutic target for improving skin homeostasis, wound healing, and broader metabolic health.
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