Premature Graying of Hair: A Comprehensive Review and Recent Insights

August 2024 in “ Indian Dermatology Online Journal ”

Kavita Poonia, Mala Bhalla

premature graying of hair oxidative stress antioxidant treatments gene therapy nutritional deficiencies

TLDR Premature graying of hair is mainly caused by genetics, stress, and environment, with potential treatments being explored.

Premature graying of hair (PMGH) is influenced by genetic, environmental, and biochemical factors, with oxidative stress and reactive oxygen species (ROS) playing a key role in disrupting melanocyte function. Genetic deficiencies, such as in BCL-2 and MITF, and external factors like UV radiation and smoking, contribute to PMGH. There are mixed findings on the association between PMGH and systemic diseases like cardiovascular issues. Current treatments, including oral supplements and topical solutions, show inconsistent results, with relapse being common. Emerging treatments focus on oxidative stress and genetic factors, with future therapies potentially involving stem cell approaches and new drugs, though more research is needed.

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research Cardiovascular Risk Markers in Premature Canities

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research A Clinical Study of Premature Graying and Its Association with Hemoglobin, Ferritin, and Calcium Levels

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research Analysis of Zinc and Copper Serum Levels in Premature Hair Graying at a Young Age

1 citations , February 2022 in “Open Access Macedonian Journal of Medical Sciences”

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research Premature Graying of Hair: Risk Factors, Co-Morbid Conditions, Pharmacotherapy and Reversal—A Systematic Review and Meta-Analysis

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research Topical RT1640 Treatment Effectively Reverses Gray Hair and Stem Cell Loss in a Mouse Model of Radiation-Induced Canities

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research Medication-Induced Repigmentation of Gray Hair: A Systematic Review

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research Serum Levels of Lead and Selenium in Patients with Premature Graying of the Hair

1 citations , September 2019 in “Journal of cosmetic dermatology”

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research Flavonoids with Two Hydroxyl Groups in the B-Ring Promote Pigmented Hair Regeneration

13 citations , August 2019 in “Biological & Pharmaceutical Bulletin”

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research Therapeutics of Premature Hair Graying: A Long Journey Ahead

12 citations , May 2019 in “Journal of cosmetic dermatology”

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research A Review of the Etiologies, Clinical Characteristics, and Treatment of Canities

7 citations , February 2019 in “International Journal of Dermatology”

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research Case Report on Premature Hair Graying Treated with Melitane 5% and Oral Hair Supplements

6 citations , January 2019 in “Indian Journal of Pharmacology”

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research Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials

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research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

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research Nonscarring Diffuse Hair Loss in Women: A Clinico-Etiological Study from a Tertiary Care Center in North-West India

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research Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-Sectional Study

5 citations , January 2018 in “Acta dermato-venereologica”

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research Relationship Between Trace Elements and Premature Hair Graying

17 citations , January 2018 in “International Journal of Trichology”

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research Association of Epidemiological and Biochemical Factors with Premature Graying of Hair: A Case-Control Study

16 citations , January 2018 in “International journal of trichology”

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Improvement of Hair Graying During Treatment of Male Pattern Hair Loss Using 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide Injections

research Improvement of Hair Graying During Treatment of Male Pattern Hair Loss Using 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide Injections

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research Demographic Characteristics and Association of Serum Vitamin B12, Ferritin, and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases

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research Biology of Hair Pigmentation and Its Role in Premature Canities

15 citations , January 2017 in “Pigment International”

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research Canities Subita: Sudden Blanching of the Hair in History and Literature

6 citations , February 2016 in “International Journal of Dermatology”

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research Factors Associated With Premature Hair Graying in a Young Indian Population

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research Association of Premature Hair Graying with Family History, Smoking, and Obesity: A Cross-Sectional Study

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research Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

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research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress

67 citations , August 2013 in “International Journal of Cosmetic Science”

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research Premature Graying of Hair: Causes, Associations, and Treatments

47 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

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research Epidemiological and Investigative Study of Premature Graying of Hair in Higher Secondary and Pre-University School Children

35 citations , January 2013 in “International Journal of Trichology”

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research Premature Hair Whitening Is an Independent Predictor of Carotid Intima-Media Thickness in Young and Middle-Aged Men

16 citations , January 2013 in “Internal Medicine”

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research A Retrospective Case-Control Study of Modifiable Risk Factors and Cutaneous Markers in Indian Patients with Young Coronary Artery Disease

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The Degree of Premature Hair Graying as an Independent Risk Marker for Coronary Artery Disease: A Predictor of Biological Age Rather Than Chronological Age

research The Degree of Premature Hair Graying as an Independent Risk Marker for Coronary Artery Disease: A Predictor of Biological Age Rather Than Chronological Age

17 citations , June 2012 in “The Anatolian journal of cardiology”

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research Sudden Whitening of the Hair in an 82-Year-Old Woman: The 'Overnight Greying' Phenomenon

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research Serum Iron, Zinc, and Copper Concentration in Premature Graying of Hair

26 citations , October 2011 in “Biological trace element research”

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research Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation

240 citations , April 2011 in “Pigment Cell & Melanoma Research”

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research Repigmentation of Hair After Latanoprost Therapy

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research Aging of the Hair Follicle Pigmentation System

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research Oxidative Stress in Aging of Hair

126 citations , January 2009 in “International Journal of Trichology”

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research Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage

210 citations , May 2006 in “The FASEB journal”

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research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production

450 citations , January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

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research Protective Effect of Superoxide Dismutase Against Hair Graying in a Mouse Model

12 citations , November 2004 in “Photochemistry and Photobiology”

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research Hair Cycle and Hair Pigmentation: Dynamic Interactions and Changes Associated with Aging

152 citations , December 2003 in “Micron”

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Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

research Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

210 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

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research Mode of Redifferentiation and Melanogenesis of Melanocytes in Mouse Hair Follicles

44 citations , April 1979 in “Journal of Ultrastructure Research”