Cardiovascular Risk Markers in Premature Canities

July 2022 in “ Indian Journal of Dermatology Venereology and Leprology ”

Suparna Das, Ram Chander, Taru Garg, Vibhu Mendiratta, Ritu Singh, Sarita Sanke

premature canities hair greying cardiovascular risk markers blood pressure fasting blood sugar serum insulin hs-CRP HOMA-IR HDL IL-6 early hair greying high blood pressure high fasting blood sugar low HDL interleukin-6

Studysummary This study found that patients with premature greying of hair had significant abnormalities in cardiovascular risk markers, including elevated IL-6 levels, compared to healthy controls.

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The study examined cardiovascular risk markers in 40 patients with premature canities compared to 40 healthy controls, finding that those with early hair greying had higher blood pressure, fasting blood sugar, serum insulin, hs-CRP, and HOMA-IR, with lower HDL levels. Elevated IL-6 levels were also more common in these patients, suggesting an increased risk for cardiovascular disease. The study recommended screening and counseling to prevent cardiovascular events, despite limitations such as a small sample size and subjective assessment of canities severity.

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Research cited in this study

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research Relationship Between Trace Elements and Premature Hair Graying

17 citations , January 2018 in “International Journal of Trichology”

This study found that patients with premature hair graying had lower serum levels of iron, copper, and calcium, which correlated with the severity of graying.

research Relationship Between Trace Elements and Premature Hair Graying

7 citations , January 2018 in “PubMed”

In this study, reduced serum levels of iron, copper, and calcium were associated with premature graying of hair, suggesting that supplementation might help, but more research is needed to fully understand the relationship.

research Association of Epidemiological and Biochemical Factors with Premature Graying of Hair: A Case-Control Study

16 citations , January 2018 in “International journal of trichology”

This study observed that individuals with premature hair graying had lower levels of certain serum nutrients and lifestyle factors like stress and smoking may contribute; hair oiling appeared protective.

research Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-Sectional Study

5 citations , January 2018 in “Acta dermato-venereologica”

This study identified an association between premature hair greying and larger waist circumference among young healthy subjects.

research Metabolic Syndrome in the Spectrum of Hair Graying

1 citations , December 2017 in “The Medical journal of Basrah University”

This study found that patients with metabolic syndrome experienced the onset of gray hair at an earlier age compared to the control group.

research Demographic Characteristics and Association of Serum Vitamin B12, Ferritin, and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases

16 citations , January 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This study found that premature hair graying is strongly associated with a family history, Vitamin B12 deficiency, and hypothyroidism, with onset as early as 5 years in patients in Gurugram, India.

research Factors Associated With Premature Hair Graying in a Young Indian Population

20 citations , January 2016 in “International journal of trichology”

In this study, premature hair graying in Indian patients under 25 was associated with low levels of serum ferritin, Vitamin B12, and high-density lipoprotein cholesterol.

research Association of Premature Hair Graying with Family History, Smoking, and Obesity: A Cross-Sectional Study

46 citations , December 2014 in “Journal of The American Academy of Dermatology”

This study found that smoking, obesity, and family history are significant risk factors for premature hair graying in young men.

research Epidemiological and Investigative Study of Premature Graying of Hair in Higher Secondary and Pre-University School Children

35 citations , January 2013 in “International Journal of Trichology”

This study found that serum calcium, serum ferritin, and vitamin D3 levels were lower in students with premature graying of hair compared to controls, suggesting a potential role in the condition.

research Premature Hair Whitening Is an Independent Predictor of Carotid Intima-Media Thickness in Young and Middle-Aged Men

16 citations , January 2013 in “Internal Medicine”

This study found that premature hair whitening intensity is independently associated with increased carotid artery intima-media thickness, suggesting a link between hair whitening and cardiovascular risk.

research A Retrospective Case-Control Study of Modifiable Risk Factors and Cutaneous Markers in Indian Patients with Young Coronary Artery Disease

45 citations , June 2012 in “JRSM Cardiovascular Disease”

In this study, premature coronary artery disease in Indians under 40 was linked to factors like dyslipidemia, low HDL-C, smoking, and central obesity, with cutaneous markers significantly associated.

research Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage

210 citations , May 2006 in “The FASEB journal”

This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.

research Protective Effect of Superoxide Dismutase Against Hair Graying in a Mouse Model

33 citations , January 2004 in “Photochemistry and Photobiology”

This study found that applying superoxide dismutase (SOD) gel on mice protected against hair graying caused by UV-A and psoralen exposure, suggesting photosensitization may be a factor in hair aging.