Evaluation of Markers of Inflammation and Oxidative Stress in Patients with Premature Canities

This study investigated the relationship between premature canities (PC), inflammatory markers, and micronutrient deficiencies in 100 participants aged ≤ 25 years, including 50 patients with PC and 50 matched controls. The findings revealed that patients with PC had significantly lower serum levels of vitamin D and vitamin B12 compared to controls, and a higher prevalence of family history, suggesting a genetic or epigenetic component. Additionally, the monocyte-to-HDL cholesterol ratio (MHR) was significantly elevated in patients with PC. However, no significant associations were found between micronutrient deficiencies and inflammatory markers. The study's limitations include its single-centre design, small sample size, and cross-sectional nature, which restrict the generalizability and ability to establish causality.