Premature Hair Graying: A Multifaceted Phenomenon

December 2024 in “ International Journal of Dermatology ”

Deesha Desai, Maria Karim, Ambika Nohria, Carli D. Needle, Anna Brinks, Caitlin A. Kearney, Amy Ridge, Natasha Atanaskova Mesinkovska, Jerry Shapiro, Kristen I. Lo Sicco

premature hair graying genetics oxidative stress smoking diet psychological impacts health conditions treatments

TLDR Premature hair graying is caused by genetics, stress, and lifestyle, and affects mental health.

Premature hair graying (PHG) is a multifaceted condition influenced by genetic factors, oxidative stress, and external elements like smoking and UV radiation. Up to 90% of PHG variability is attributed to genetics, with specific SNPs identified. Oxidative stress damages hair follicles, affecting melanin production. Nutritional deficiencies, medical conditions, and lifestyle factors also contribute to PHG. Current treatments focus on cosmetic solutions, while emerging therapies like monoclonal antibodies and tyrosine kinase inhibitors show potential for hair repigmentation. The review emphasizes the need for further research into genetic pathways and effective treatments, advocating for a holistic approach to managing PHG.

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research The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

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research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

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research All That a Dermatotrichologist Needs to Know About Hair Camouflage: A Comprehensive Review

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research Efficacy and Safety Profile of Oral Spironolactone Use for Androgenic Alopecia: A Systematic Review

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research Minoxidil: A Comprehensive Review

16 citations , June 2021 in “Journal of Dermatological Treatment”

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research Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

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research Exploring the Possibility of Predicting Human Head Hair Greying from DNA Using Whole-Exome and Targeted NGS Data

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research Premature Graying of Hair: Risk Factors, Co-Morbid Conditions, Pharmacotherapy and Reversal—A Systematic Review and Meta-Analysis

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research 5-Alpha Reductase Inhibitors in Androgenetic Alopecia: Shifting Paradigms, Current Concepts, Comparative Efficacy, and Safety

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research Oral Minoxidil Improves Background Hair Thickness in Lichen Planopilaris

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research Repigmentation and New Hair Growth After Anti-Interleukin-17 Therapy with Secukinumab for Psoriasis

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research Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-Sectional Study

5 citations , January 2018 in “Acta dermato-venereologica”

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research Three Streams for the Mechanism of Hair Graying

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research Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation

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research Demographic Characteristics and Association of Serum Vitamin B12, Ferritin, and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases

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research Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review

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research A Genome-Wide Association Scan in Admixed Latin Americans Identifies Loci Influencing Facial and Scalp Hair Features

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research Factors Associated With Premature Hair Graying in a Young Indian Population

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research Hair Coloration by Gene Regulation: Fact or Fiction?

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research Association of Premature Hair Graying with Family History, Smoking, and Obesity: A Cross-Sectional Study

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research Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors

46 citations , April 2014 in “PLOS ONE”

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research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress

67 citations , August 2013 in “International Journal of Cosmetic Science”

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research Premature Hair Whitening Is an Independent Predictor of Carotid Intima-Media Thickness in Young and Middle-Aged Men

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research Epidemiological and Investigative Study of Premature Graying of Hair in Higher Secondary and Pre-University School Children

35 citations , January 2013 in “International Journal of Trichology”

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research Wigs and Hairpieces: Evaluating Dermatologic Issues

22 citations , May 2012 in “Dermatologic Therapy”

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research Hair Repigmentation Associated with the Use of Lenalidomide: Graying May Not Be an Irreversible Process

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An 81-year-old man's white hair began to regain its original color while he was treated with lenalidomide, suggesting that graying hair might be reversible.

research Serum Iron, Zinc, and Copper Concentration in Premature Graying of Hair

26 citations , October 2011 in “Biological trace element research”

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research Innovative Use of Spironolactone as an Antiandrogen in the Treatment of Female Pattern Hair Loss

53 citations , May 2010 in “PubMed”

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research Why Some Women Look Young for Their Age

175 citations , November 2009 in “PLOS ONE”

Women look young for their age due to larger lips, less sun damage, and genes that prevent gray hair and wrinkles.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Repigmentation of Gray Hair After Thyroid Hormone Treatment

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research Hair Loss in Women

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research Repigmentation of Gray Hair After Thyroid Hormone Treatment

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research Aging of Hair

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research Treatment of Female Pattern Hair Loss With Oral Antiandrogens

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research Protective Effect of Superoxide Dismutase Against Hair Graying in a Mouse Model

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research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

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research Minoxidil: Mechanisms of Action on Hair Growth

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research Tyrosine Kinase Inhibition and Grey Hair

59 citations , March 2003 in “The Lancet”

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.

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research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

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research Finasteride

125 citations , January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.