Tyrosine Kinase Inhibition and Grey Hair

    March 2003 in “ The Lancet ”
    Caroline Robert, Alan Spatz, Sandrine Faivre, Jean‐Pierre Armand, Eric Raymond
    TLDR Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.
    The document reported that the tyrosine kinase inhibitor imatinib led to repigmentation of grey hair in 9 out of 133 patients, potentially due to its inhibition of the c-KIT receptor. Conversely, the drug SU11428, which blocks receptors for VEGF, PDGF, and stem-cell factor, caused hair depigmentation in 18 out of 28 cancer patients during a phase 1 trial. This depigmentation was reversible, with normal pigmentation returning after treatment cessation. These findings indicated that different combinations of tyrosine kinase receptor blockades could have varying effects on hair pigmentation, suggesting the need for further research into the molecular pathways involved in melanocyte differentiation.
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