Two Mouse Mutations Mapped to Chromosome 11 with Differing Morphologies but Similar Progressive Inflammatory Alopecia

May 2005 in “ Experimental Dermatology ”

Geoffrey A. Wood, Ann M. Flenniken, Lucy R. Osborne, Craig Fleming, Igor Vukobradovic, Lily Morikawa, Qiang Xu, Rebecca Porter, S. Lee Adamson, Janet Rossant, Colin McKerlie

alopecia inflammatory alopecia hair loss dermal cellularity inflammatory cell infiltration MHC class I expression follicular epithelium autoantigens scarring alopecia inflammation immune response

Studysummary This study reports that two mouse models of scarring alopecia exhibit similar patterns of hair loss progression despite histological differences in inflammatory cell localization and MHC class I expression.

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