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GlossaryAutoantigens

proteins mistakenly attacked by the immune system

Autoantigens are proteins or molecules that are naturally present in the body but are mistakenly targeted by the immune system as if they were harmful invaders. This misidentification can lead to autoimmune diseases, where the body's immune response attacks its own tissues, such as in conditions like alopecia areata, where the immune system targets hair follicles.

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research Computer-Assisted Epitope Prediction Revealed Potential Autoantigens Associated with Human Alopecia Areata

April 2018 in “Journal of Investigative Dermatology”

Melanogenesis-related proteins may trigger immune responses in alopecia areata patients.

research A Nonredundant Human Protein Chip for Antibody Screening and Serum Profiling

117 citations, September 2003 in “Molecular & cellular proteomics”

The technology can help diagnose and subtype autoimmune diseases by identifying specific autoantibodies.

research Protein Microarrays: Analytical and Functional Applications in Biochemistry and Molecular Biology

73 citations, April 2006 in “BioTechniques”

Protein microarrays are highly sensitive tools useful for disease diagnosis and studying proteins.

research Immunology of Alopecia Areata

23 citations, January 2020 in “Central-European Journal of Immunology/Central European Journal of Immunology”

Alopecia areata, a type of hair loss, is likely an autoimmune disease with a genetic link, but its exact cause is still unknown.

research Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implications of Post-Translational Modifications

11 citations, June 2022 in “Frontiers in immunology”

New protein changes may be involved in the immune attack on hair follicles in alopecia areata.

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