Cicatricial (Scarring) Alopecia: Clinical Presentations, Etiologies, and Histopathologic Features

    April 2001 in “ International Journal of Dermatology ”
    Virendra Sehgal, Govind Srivastva, Pramila Bajaj
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    TLDR Different types of scarring alopecia may be stages of one disease, and accurate diagnosis is crucial to prevent permanent hair loss.
    The 2001 document reviews cicatricial (scarring) alopecia, detailing the clinical presentations, potential etiologies, and histopathologic features of various forms such as lichen planopilaris, pseudopelade, discoid lupus erythematosus, folliculitis decalvans, and others. It highlights the importance of histopathology and immunofluorescence in diagnosis, noting the difficulty in differentiating between early lesions of these conditions. The review suggests that different scarring alopecias may represent stages of a single disease process, emphasizing the need for accurate diagnosis through detailed history, laboratory data, and advanced techniques to prevent permanent hair follicle damage.
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      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 2 weeks ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

      community Comprehensive Microneedling Guide

      in Microneedling  293 upvotes 2 years ago
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