Cicatricial (Scarring) Alopecia: Clinical Presentations, Etiologies, and Histopathologic Features

    April 2001 in “ International Journal of Dermatology ”
    Virendra Sehgal, Govind Srivastva, Pramila Bajaj
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    TLDR Different types of scarring alopecia may be stages of one disease, and accurate diagnosis is crucial to prevent permanent hair loss.
    The 2001 document reviews cicatricial (scarring) alopecia, detailing the clinical presentations, potential etiologies, and histopathologic features of various forms such as lichen planopilaris, pseudopelade, discoid lupus erythematosus, folliculitis decalvans, and others. It highlights the importance of histopathology and immunofluorescence in diagnosis, noting the difficulty in differentiating between early lesions of these conditions. The review suggests that different scarring alopecias may represent stages of a single disease process, emphasizing the need for accurate diagnosis through detailed history, laboratory data, and advanced techniques to prevent permanent hair follicle damage.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  94 upvotes 1 year ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  54 upvotes 11 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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