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Did you mean Chromatin Remodeling?

Glossary Chromatin Remodeling

restructuring of DNA-protein complexes to regulate gene expression

Chromatin remodeling refers to the dynamic modification of the structure of chromatin, which is the complex of DNA and proteins in the nucleus of a cell. This process involves the repositioning or restructuring of nucleosomes (the basic units of chromatin) to either expose or hide specific DNA regions, thereby regulating gene expression. For a layperson, it's like rearranging books on a shelf to make certain ones easier to read, while for a professional, it involves understanding the specific molecular mechanisms and enzymes, such as ATP-dependent chromatin remodelers, that facilitate these changes.

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research ATP-dependent chromatin remodeling during mammalian development

182 citations , August 2016 in “Development”

This review discusses the roles and mechanisms of chromatin remodelers and their subunits in mammalian development, but reports no new experimental results.

research p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis

166 citations , September 2011 in “The Journal of Cell Biology”

This study found that the p63 transcription factor plays a role in epidermal morphogenesis by regulating Satb1 expression, impacting chromatin architecture and gene expression in epidermal progenitor cells.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets.

39 citations , January 2016 in “PubMed”

This review discusses the role of epidermal differentiation complex genes and epigenetic mechanisms in skin development and certain diseases, emphasizing their potential for improving drug development and delivery systems but provides no new experimental results.

research Le gènehairlessde la souris

4 citations , May 2006 in “médecine/sciences”

This study suggests that the hairless gene encodes a nuclear factor important for hair follicle integrity, and its absence leads to hair follicle loss and defects in tissue development.

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