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    Glossary Cornified Envelope

    tough, protective layer in the outermost skin part

    The cornified envelope is a tough, protective layer found in the outermost part of the skin, known as the stratum corneum. It is composed of cross-linked proteins and lipids, providing a barrier against environmental damage, pathogens, and water loss. This structure is crucial for maintaining skin integrity and function.

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    1. Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes Differentiation · 1992 · 64 citations
    2. Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes Experimental Dermatology · 2019 · 44 citations
    3. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    4. Epithelial barrier function: assembly and structural features of the cornified cell envelope BioEssays · 2002 · 425 citations
    5. The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein Journal of Biological Chemistry · 1993 · 161 citations
    6. Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes 1998 · 99 citations
    7. The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein 1993 · 2 citations
    8. Involucrin: A Constituent of Cross-Linked Envelopes and Marker of Squamous Maturation 1986 · 23 citations
    9. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    10. Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets. PubMed · 2016 · 39 citations
    11. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    12. Skin transcriptome profiling of Changthangi goats highlights the relevance of genes involved in Pashmina production Scientific reports · 2020 · 22 citations
    13. Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines American Journal Of Pathology · 2018 · 21 citations
    14. The Expression of Vitamin D-Upregulated Protein 1 in Skin and its Interaction with Sciellin in Cultured Keratinocytes 2003 · 18 citations
    15. Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function Cell Death and Disease · 2015 · 17 citations
    16. Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types Journal of Veterinary Science · 2012 · 15 citations
    17. Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy International journal of trichology · 2010 · 10 citations
    18. Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2 2022 · 8 citations
    19. Animal models of human skin disease Experimental Dermatology · 2004 · 4 citations
    20. [Difference between the hair follicle cell and epidermal keratinocyte in vitro]. PubMed · 1990
    21. Lysine Carboxymethyl Cysteinate (LCC) Protects the Epidermis from UVB-Induced Barrier Damage Through the Activation of Autophagy Biology · 2026
    22. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
    23. The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function) Free Radical Biology and Medicine · 2015
    24. Novel insights into hair structure and the effects of chemical stressors on hair and skin using label-free advanced light microscopy Durham e-Theses (Durham University) · 2017
    25. Transglutaminase 5 Expression in Human Hair Follicle Journal of Investigative Dermatology · 2005 · 28 citations
    26. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001 · 130 citations
    27. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    28. Trichohyalin Mechanically Strengthens the Hair Follicle 2003 · 108 citations
    29. Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes Experimental Dermatology · 2000 · 58 citations
    30. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology British Journal of Dermatology · 2012 · 33 citations