TLDR Keratin-associated proteins are part of the developing hair fiber cuticle.
The study from January 1, 2010, used immunoelectron microscopy to locate keratin-associated proteins (KAP) 5.1 and 10.1 in developing hair fiber cuticle cells, finding them primarily in the exocuticle and a-layer, while cornified envelope proteins involucrin and loricrin were absent. This suggested a simpler protein composition of the fiber cuticle than previously thought, with KAP proteins potentially cross-linked by cuticle TGase 3. The findings provided insights into the structural organization and functional roles of KAPs in hair fiber development, contributing to a better understanding of hair biology and the molecular mechanisms of hair formation.
22 citations,
October 1996 in “Dermatologic clinics” Understanding intermediate filaments helps explain hair health and related diseases.
67 citations,
December 1990 in “The journal of cell biology/The Journal of cell biology” Researchers found genes for cysteine-rich proteins that form the protective layer of hair in humans and sheep.
116 citations,
April 1986 in “The journal of cell biology/The Journal of cell biology” Trichohyalin is a protein in hair follicles that helps form hair filaments.
62 citations,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.
Water and fatty acids affect hair's surface differently based on hair damage, and models can help understand hair-cosmetic interactions.
May 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” KAP-depleted hair causes less immune response and is more biocompatible for implants.
38 citations,
October 2011 in “Analytical biochemistry” Hair proteins have weak spots in their α-helical segments.
Human hair keratins can self-assemble and support cell growth, useful for biomedical applications.
