The Dark and the Bright Sides of the Transcription Factor Nrf2 in Skin Protection and Disease
August 2015
in “
Free Radical Biology and Medicine
”
Nrf2 keratinocytes antioxidant enzymes cytoprotective proteins reactive oxygen species ROS UV light UVB damage cornified envelope proteins secretory leukocyte peptidase inhibitor corneocyte fragility desquamation epidermal lipid barrier keratinocyte hyperproliferation epidermal barrier function hyperkeratosis inflammation cyst formation
Studysummary This study found that Nrf2 activation protected keratinocytes from UVB damage but also caused thickening, inflammation, and cysts, limiting its therapeutic potential for skin protection.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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