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research Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1 ^-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation

87 citations , March 2007 in “Biological Chemistry”

In this study, targeted deletion of the stearoyl-CoA desaturase 1 gene in mice disrupted the epidermal lipid barrier, leading to increased water loss, impaired thermoregulation, and metabolic issues.

research 732 Ceramide synthase 4 controls epidermal lipid composition and barrier function

April 2018 in “Journal of Investigative Dermatology”

This study found that inactivating CerS4 in mouse epidermis disrupts lipid homeostasis and is crucial for maintaining, but not forming, the skin barrier.

research Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation

34 citations , August 2019 in “Journal of Allergy and Clinical Immunology”

mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.

research A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

98 citations , December 2015 in “The Journal of Cell Biology”

In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.

research Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier

23 citations , March 2017 in “Journal of Investigative Dermatology”

An artificial lipid barrier can restore hair growth in cases of SCD1 deficiency.

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community Why you can still look forward to PP405 and JXL-069

22 upvotes 1 month ago

PP405 and JXL-069 are the same compound, but users experienced no results due to flawed application methods. The topical gel formulation of PP405 is designed to target hair follicle stem cells effectively, unlike liquid solutions that fail to penetrate deeply.

community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

8 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

community Topical Dutasteride. Does it work?

in Finasteride/Dutasteride 13 upvotes 2 years ago

Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

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learn Lipodermal base

learn Ceramide EOP

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