Effect of Hataedock Treatment on Epidermal Structure Maintenance Through Intervention in the Endocannabinoid System
January 2020
in “
Evidence-based Complementary and Alternative Medicine
”
TLDR Hataedock treatment improved skin health and reduced atopic dermatitis symptoms by enhancing the skin barrier and reducing inflammation.
The study investigated the effects of Hataedock (HTD) on skin barrier maintenance in NC/Nga mice with atopic dermatitis induced by Dermatophagoides farinae. HTD, administered at 20 mg/kg, significantly reduced clinical scores and improved histological features by intervening in the endocannabinoid system (ECS). This intervention increased the expression of cannabinoid receptors CB1, CB2, and GPR55, as well as proteins like filaggrin and involucrin, which are crucial for epidermal barrier maintenance. HTD also elevated E-cadherin and GPx4 expression, reduced CD1A levels, and increased inflammatory cell apoptosis. Additionally, it decreased the production of phosphorylated signaling proteins and epidermal thickness. Genistein, an active component of HTD, was more effective in lipid barrier formation than palmitoylethanolamide (PEA). Overall, HTD alleviated atopic dermatitis symptoms by maintaining skin homeostasis, enhancing barrier formation, and reducing inflammation through ECS modulation.
