Effect of Hataedock Treatment on Epidermal Structure Maintenance Through Intervention in the Endocannabinoid System
January 2020
in “
Evidence-based Complementary and Alternative Medicine
”
TLDR Hataedock treatment improved skin health and reduced atopic dermatitis symptoms by enhancing the skin barrier and reducing inflammation.
The study investigated the effects of Hataedock (HTD) on atopic dermatitis (AD) in NC/Nga mice, focusing on the endocannabinoid system (ECS) and skin barrier function. HTD, derived from fermented Glycine max Merr., was administered at 20 mg/kg and significantly alleviated AD symptoms by reducing clinical scores and improving histological features. It enhanced the expression of cannabinoid receptors (CB1, CB2, GPR55) and proteins involved in skin barrier function (filaggrin, involucrin, loricrin, Lass2), while reducing inflammation and promoting apoptosis of inflammatory cells. HTD also decreased phosphorylated protein production and epidermal thickness. Genistein, an active component of HTD, was more effective in lipid barrier formation than palmitoylethanolamide (PEA). The study concluded that HTD could be a promising treatment for improving skin barrier function and reducing inflammation in AD by modulating the ECS.
