TLDR The exact identity of skin stem cells and how skin cells differentiate is not fully known.
The document reviews research on the identification of epidermal stem cells and the process of epidermal differentiation, focusing on studies involving lineage tracing, clonal growth analysis in the basal layer of the epidermis, hair follicle and interfollicular epidermal stem cells, and the role of Wnt signaling in developmental patterning and cell differentiation. The paper collates and analyzes existing literature and proposes models for the cellular composition of the basal layer and the mechanism of epidermal differentiation. However, it acknowledges that a definitive identification of epidermal stem cells remains unknown and the full mechanism of epidermal differentiation is not completely understood.
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211 citations
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January 2019 in “Nature Cell Biology” Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.
54 citations
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January 2016 in “Cell reports” Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.
207 citations
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April 2012 in “Development” Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
168 citations
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August 2009 in “EMBO molecular medicine” Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.
835 citations
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October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
May 2019 in “Journal of Investigative Dermatology” Wnt-signaling is regulated differently in skin cells and immune responses during wound healing.
May 2017 in “Journal of Dermatological Science” Certain flavonoids can improve the growth of pigmented hair in mice.
