Basal Cells in the Epidermis and Epidermal Differentiation

June 2021 in “ Research Square (Research Square) ”

Reeta Singh

epidermal stem cells epidermal differentiation lineage tracing clonal growth analysis basal layer hair follicle interfollicular epidermal stem cells Wnt signaling developmental patterning cell differentiation

TLDR The exact identity of skin stem cells and how skin cells differentiate is not fully known.

The document reviews research on the identification of epidermal stem cells and the process of epidermal differentiation, focusing on studies involving lineage tracing, clonal growth analysis in the basal layer of the epidermis, hair follicle and interfollicular epidermal stem cells, and the role of Wnt signaling in developmental patterning and cell differentiation. The paper collates and analyzes existing literature and proposes models for the cellular composition of the basal layer and the mechanism of epidermal differentiation. However, it acknowledges that a definitive identification of epidermal stem cells remains unknown and the full mechanism of epidermal differentiation is not completely understood.

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

211 citations, November 2018 in “Nature Cell Biology”

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

54 citations, January 2016 in “Cell reports”

Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations, March 2012 in “Development”

Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.

research Epidermal Stem Cell Diversity and Quiescence

168 citations, August 2009 in “EMBO molecular medicine”

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations, October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

182 citations, May 2003 in “Development”

research c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

338 citations, April 2001 in “Current Biology”

Related Community Posts Join

6 / 54 results

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Clearing the air on how non-surgical treatments really work

18 upvotes 5 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community A Scientific Perspective in Microneedling for Alopecia

in Microneedling 43 upvotes 4 years ago

The post and conversation are about microneedling as a treatment for alopecia. It provides a comprehensive review of scientific literature on the technique and its application.

community Is it possible for androgenic alopecia to begin at early adolescent years?

in Chat 70 upvotes 1 year ago

Hair loss can begin in early adolescence and cause mental anguish. Treatments mentioned include eating cruciferous vegetables, engaging in physical activity, and maintaining scalp hygiene.

Related Research

2 / 2 results

research Temporal-Spatial Activation of Wnt-Signaling Within Type 1 and Type 2 Immunity During Wound Healing

April 2019 in “Journal of Investigative Dermatology”

Wnt-signaling is regulated differently in skin cells and immune responses during wound healing.

research The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation

April 2017 in “Journal of Dermatological Science”

Certain flavonoids can improve the growth of pigmented hair in mice.