Basal Cells in the Epidermis and Epidermal Differentiation

June 2021 in “ Research Square (Research Square) ”

Reeta Singh

epidermal stem cells epidermal differentiation lineage tracing clonal growth analysis basal layer hair follicle interfollicular epidermal stem cells Wnt signaling developmental patterning cell differentiation

TLDR The exact identity of skin stem cells and how skin cells differentiate is not fully known.

The document reviews research on the identification of epidermal stem cells and the process of epidermal differentiation, focusing on studies involving lineage tracing, clonal growth analysis in the basal layer of the epidermis, hair follicle and interfollicular epidermal stem cells, and the role of Wnt signaling in developmental patterning and cell differentiation. The paper collates and analyzes existing literature and proposes models for the cellular composition of the basal layer and the mechanism of epidermal differentiation. However, it acknowledges that a definitive identification of epidermal stem cells remains unknown and the full mechanism of epidermal differentiation is not completely understood.

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Research cited in this study

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research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing

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research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

54 citations, January 2016 in “Cell reports”

Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

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182 citations, May 2003 in “Development”

Myc activation reduces skin stem cells by affecting cell adhesion.

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations, April 2001 in “Current Biology”

c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.

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