Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid

The study examined the effects of salicylic acid peeling on hairless mice skin, using concentrations of 7.5%, 15.0%, and 30.0%. The 30.0% concentration led to significant exfoliation, epidermal thinning, and increased basal cell proliferation within 24 hours, without causing degeneration or inflammation. Lower concentrations caused minimal changes. The findings indicated that salicylic acid could safely regenerate the epidermis and papillary dermis by injuring the cornified layer without inflammation, suggesting its potential as a chemical peeling method for individuals at risk of pigmentary disorders and keloids. The macrogol vehicle was less irritating than ethanol, which could be advantageous for sensitive patients.