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GlossaryStratum Corneum (Cornified Layer)

outermost skin layer composed of dead, keratinized cells

The Stratum Corneum, also known as the Horny Layer, is the outermost layer of the epidermis, consisting of dead, flattened skin cells that are rich in keratin. This layer acts as a primary barrier to protect underlying tissues from infection, dehydration, and mechanical stress, playing a crucial role in maintaining skin hydration and overall health.

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Research

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research The Structure of the Cornified Claw Sheath in the Domesticated Cat (Felis Catus): Implications for the Claw-Shedding Mechanism and the Evolution of Cornified Digital End Organs

45 citations, April 2009 in “Journal of anatomy”

Cat claws stay sharp by shedding their outer layer through microcracks formed during activities.

research Hair Follicle Morphogenesis and Epidermal Homeostasis in We/We Wal/Wal Mice with Postnatal Alopecia

7 citations, November 2014 in “Histochemistry and Cell Biology”

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

research Local IL-17 Orchestrates Skin Aging

1 citations, January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Blocking IL-17 signaling can delay skin aging and improve skin and hair health.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets

39 citations, January 2016 in “PubMed”

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

research Circle Hairs in a Patient with Multiple Myeloma

November 2021 in “Clinical, cosmetic and investigational dermatology”

An elderly woman with cancer improved after treatment for a rare skin condition with coiled hairs.

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community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

in Minoxidil 39 upvotes 5 years ago

Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

community 17 month update 30M FUT 2300 grafts 1 year fin/min topical

in Progress Pictures 414 upvotes 9 months ago

A user shared a 17-month update on their hair loss treatment, which included a hair transplant of 2300 grafts, using a topical solution of minoxidil and finasteride, a laser cap, and ketoconazole shampoo. They are considering another transplant and seeking honest feedback on their progress, while others share their own experiences and advice on hair loss treatments.

community I’m really tired of using minoxidil

in Minoxidil 42 upvotes 11 months ago

The user is frustrated with minoxidil's lack of results and is considering alternatives like oral minoxidil or finasteride despite concerns about side effects. Other suggestions include consulting a doctor, adjusting dosages, or considering a hair transplant.

community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

in Progress Pictures 337 upvotes 2 years ago

Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

community Derm prescribed ketoconazole 2% shampoo, claiming my case “is not bad enough yet” for fin. Second opinion?

in Treatment 85 upvotes 1 year ago

A user was prescribed ketoconazole shampoo by their dermatologist for early-stage hair loss, but is unsure if this is the right treatment. Most commenters suggest seeking a second opinion or starting finasteride treatment immediately, while a few caution about potential side effects.

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