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GlossaryStratum Corneum (Cornified Layer)

outermost skin layer composed of dead, keratinized cells

The Stratum Corneum, also known as the Horny Layer, is the outermost layer of the epidermis, consisting of dead, flattened skin cells that are rich in keratin. This layer acts as a primary barrier to protect underlying tissues from infection, dehydration, and mechanical stress, playing a crucial role in maintaining skin hydration and overall health.

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research The Structure of the Cornified Claw Sheath in the Domesticated Cat (Felis Catus): Implications for the Claw-Shedding Mechanism and the Evolution of Cornified Digital End Organs

45 citations , April 2009 in “Journal of anatomy”

Cat claws stay sharp by shedding their outer layer through microcracks formed during activities.

research Hair Follicle Morphogenesis and Epidermal Homeostasis in We/We Wal/Wal Mice with Postnatal Alopecia

7 citations , November 2014 in “Histochemistry and Cell Biology”

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

research Histologic Changes in the Skin of Hairless Mice Following Peeling With Salicylic Acid

74 citations , November 2000 in “Archives of Dermatology”

Salicylic acid can safely exfoliate and regenerate skin without causing inflammation.

research Efficient In Vitro Transfection of Human Keratinocytes with an Adenovirus-Enhanced Receptor-Mediated System

16 citations , April 2000 in “Journal of Investigative Dermatology”

The AVET system effectively delivers genes to human keratinocytes and may help treat skin diseases.

research Local IL-17 Orchestrates Skin Aging

1 citations , January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Blocking IL-17 signaling can delay skin aging and improve skin and hair health.

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community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

in Minoxidil 40 upvotes 6 years ago

Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

community 17 month update 30M FUT 2300 grafts 1 year fin/min topical

in Progress Pictures 414 upvotes 1 year ago

A user shared a 17-month update on their hair loss treatment, which included a hair transplant of 2300 grafts, using a topical solution of minoxidil and finasteride, a laser cap, and ketoconazole shampoo. They are considering another transplant and seeking honest feedback on their progress, while others share their own experiences and advice on hair loss treatments.

community I’m really tired of using minoxidil

in Minoxidil 42 upvotes 1 year ago

The user is frustrated with minoxidil's lack of results and is considering alternatives like oral minoxidil or finasteride despite concerns about side effects. Other suggestions include consulting a doctor, adjusting dosages, or considering a hair transplant.

community Hairloss has destroyed my Life completely

in Chat 339 upvotes 2 months ago

A young person is distressed about rapid hair loss despite using finasteride and recently starting oral minoxidil. Many suggest continuing treatment, considering dutasteride, and seeking therapy for mental health support.

community 3 months progress with Finasteride 0.5mg/daily, Minoxidil foam5% 2x daily, Stemoxydine 2x daily, Microneedling(M8) 1.5mm 1x per week, Saw Palmetto 400mg/day, peppermint and jojoba oils daily, Ketoconazole 2% shampoo 3x/week, Purador shampoo/conditioner every day.

in Progress Pictures 338 upvotes 3 years ago

Jordan-Iliad has been using a combination of finasteride, minoxidil, stemoxydine, microneedling, saw palmetto, peppermint and jojoba oils, ketoconazole shampoo, and Purador shampoo/conditioner for 3 months to treat their hair loss with stunning results. They have also recently started taking oral minoxidil 1.25mg/day in hopes of achieving even better results over the next 3 months.

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