Clinical Snippets: Insights into Dermatological Studies

    January 2016 in “ Journal of Investigative Dermatology ”
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    TLDR Some cells may slow melanoma growth, a protein could affect skin pigmentation, a gene-silencing method might treat hair defects, skin bacteria changes likely result from eczema, and a defensin protein could help treat multiple sclerosis.
    The document provides brief insights into several dermatological studies. One study showed that tumor-infiltrating dendritic cells (TIDCs) in mice change from immunoinhibitory to immunostimulatory over time, potentially delaying melanoma growth. Another study found that secreted frizzled-related protein 2 (sFRP2) acts as a melanogenic stimulator in human melanocytes, suggesting a role in UV-induced hyperpigmentary disorders and offering potential treatment strategies. A third study demonstrated the use of allele-specific RNA interference to correct hair shaft defects caused by dominant-negative keratin mutations in mice, indicating a potential approach for treating hair structural abnormalities. Additionally, research on mice deficient in certain cornified envelope proteins suggested that an altered skin microbiome in atopic dermatitis is a consequence rather than a cause of the disease. Lastly, a study on murine ß-defensin 14 (mBD14) showed its potential as a safe treatment strategy for multiple sclerosis due to its immunosuppressive effects and ability to induce regulatory T cells.
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