Keratohyalin, Trichohyalin, and Keratohyalin-Trichohyalin Hybrid Granules: An Overview

November 1992 in “ The Journal of Dermatology ”

Motomu Manabe, W. Michael O’Guin

keratohyalin trichohyalin filaggrin keratin filaments epidermis hair follicles keratinocyte differentiation keratohyalin-trichohyalin hybrid granules

Studysummary This review discusses the roles of filaggrin and trichohyalin in keratinocyte differentiation and reports no new results; the authors introduce possible hybrid granules in tongue epithelia.

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Research cited in this study

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research The cDNA-Deduced Amino Acid Sequence for Trichohyalin, a Differentiation Marker in the Hair Follicle, Contains a 23 Amino Acid Repeat

39 citations , February 1990 in “The journal of cell biology/The Journal of cell biology”

This study identified trichohyalin as an early differentiation marker in hair follicles, with potential structural roles related to alpha-helical formations, based on the partial characterization of its cDNA in sheep.

research Cytochemistry of Trichohyalin Granules: A Possible Role in Cornification of Inner Root Sheath Cells in Hair Follicles

4 citations , April 1989 in “The Journal of Dermatology”

This study observed in mouse skin that trichohyalin granules in hair follicles transform into filamentous structures as inner root sheath cells differentiate and cornify.

research Expression of Hair-Related Keratins in a Soft Epithelium: Subpopulations of Human and Mouse Dorsal Tongue Keratinocytes Express Keratin Markers for Hair, Skin, and Esophageal Types of Differentiation

128 citations , March 1989 in “Experimental Cell Research”

Hoxc13 is important for hair and tongue development by controlling hair keratin genes.

research Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle

116 citations , April 1986 in “The journal of cell biology/The Journal of cell biology”

This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.